| 货号 | MAB1896-SP |
| 别名 | MGC129934; MGC129935; TL1A; TL1Vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; vascular endothelial growth inhibitor-192A; VEGI; VEGI192A; VEGITNF ligand-related molecule 1 | 全称 | TNF-like 1 |
| 反应种属 | Mouse |
| 应用 | Neutralization |
| 目标/特异性 | Detects mouse TL1A/TNFSF15 in ELISA. |
| 使用方法 | Neutralization: Measured by its ability to neutralize TL1A/TNFSF15-induced apoptosis in the TF‑1 human erythroleukemic cell line. Migone, T. et al. (2002) Immunity 16:479. The Neutralization Dose (ND50) is typically 0.8-4 μg/ml in the presence of 500 ng/mL Recombinant Mouse TL1A/TNFSF15. |
| 来源 | Monoclonal Rat IgG1 Clone # 820446 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 9966 (Human); 326623 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | E. coli-derived recombinant mouse TL1A/TNFSF15 Ile76-Leu252 Accession # Q5UBV8 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Sterile PBS to a final concentration of 0.5 mg/mL. |
| 背景 | TL1A is a type II transmembrane protein belonging to the TNFsuperfamily and has been designated TNFSF15. It is expressedpredominantly in endothelial cells, and its expression is inducible byTNF-alpha and IL-1 alpha. TL1A binds with high affinity to DR3/TNFRSF25 onactivated T cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
|
Apoptosis Induced by TL1A/ TNFSF15 and Neutralization by Mouse TL1A/TNFSF15 Antibody. Recombinant Mouse TL1A/TNFSF15 (Catalog # 1896-TL) induces apoptosis in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). Apoptosis elicited by Recombinant Mouse TL1A/TNFSF15 (500 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse TL1A/TNFSF15 Monoclonal Antibody (Catalog # MAB1896). The ND50 is typically 0.8-4 μg/ml. |
