| 货号 | MAB24891-SP |
| 别名 | beta-Ala-His dipeptidase; Carnosinase 1; carnosine dipeptidase 1 (metallopeptidase M20 family); Carnosine dipeptidase 1; CN1MGC102737; CNDP dipeptidase 1; CNDP1; CPGL2; CPGL2MGC142072; EC 3.4.13.20; Glutamate carboxypeptidase-like protein 2; HsT2308; MGC10825; Serum carnosinase |
| 反应种属 | Human |
| 应用 | Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects human Carnosine Dipeptidase 1/CNDP1 in direct ELISAs. |
| 使用方法 | Immunoprecipitation: 25 µg/mL Neutralization: Measured by its ability to neutralize Recombinant Human Carnosine Dipeptidase 1/CNDP1 (0.5 µg/mL, Catalog # 2489-ZN) cleavage of the fluorogenic peptide substrate L-Carnosine (0.5 mM). The Neutralization Dose (ND50) is typically 0.6 µg/mL. |
| 来源 | Monoclonal Mouse IgG1 Clone # 352213 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 84735 (Human) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Carnosine Dipeptidase 1/CNDP1 Pro28-His507 Accession # Q96KN2 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | The human CNDP1 gene encodes carnosine dipeptidase 1, a member of the M20 family of metalloproteases (1, 2). Also known as X-His dipeptidase, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), CNDP1 is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa = beta -Ala (carnosine) and Xaa = gamma -aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter fucntions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase. CNDP1 consists of a signal peptide (residues 1 to 26) and the mature chain (residues 27 to 507). The amino acid sequence of human CNDP1 is 97%, 85%, 82% and 67% identical to that of chimpanzee, canine, mouse/rat and chicken. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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